Publications by authors named "M Melhem"
Objective: Patients undergoing anterior/posterior lumbar fusion surgery can undergo either a single-stage or multistage operation, depending on surgeon preference. The goal of this study was to assess different patient outcomes between single-stage and multistage lumbar fusion procedures in a multicenter setting.
Methods: The Michigan Spine Surgery Improvement Collaborative database was queried for anterior/posterior lumbar fusion surgeries between July 2018 and January 2022.
Article Synopsis
- * The study, conducted between January and June 2023, included 89 out of 160 patients, with 44 of them (49.4%) developing HAIs, categorized based on CDC definitions.
- * The incidence of specific HAIs was noted as 21/1000 days for bloodstream infections, 10/100 urinary catheter days for urinary infections, and 34/1000 ventilator days for pneumonia, revealing that these rates are lower than those in similar hospitals in developing countries.
Article Synopsis
- Dostarlimab-gxly is a monoclonal antibody targeting the PD-1 receptor, and the RUBY study aimed to analyze its pharmacokinetics and efficacy in patients with advanced endometrial cancer.
- The study combined data from the RUBY and GARNET trials, examining the safety and efficacy of dostarlimab through regression analyses.
- Results indicated that combining dostarlimab with standard care had a minimal impact on its pharmacokinetics, with no significant adverse effects or relationships affecting patient outcomes.
Article Synopsis
- The study focuses on Trichosporon fungi, which can cause skin infections and serious diseases, particularly in certain populations in Central-West Brazil.
- Researchers isolated 25 strains, with the most common being T. asahii, and found that skin infections were particularly prevalent in males aged 21-30, especially among black men.
- Identification of the Trichosporon species involved a combination of traditional phenotypic methods and advanced molecular techniques, specifically analyzing DNA sequences.
Airborne spp. are critical pathogens that cause nosocomial infections in hospitals. Despite their importance, little is known about the distribution of species in the indoor air of hospitals in Brazil.
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