Publications by authors named "M Meissler"
Article Synopsis
- Fin development and regeneration in teleost fish, particularly zebrafish, involve complex biological processes that depend on genetic factors, signaling pathways, and the extracellular matrix (ECM) for proper structure.
- Researchers created a mutant zebrafish line with reduced fndc3a protein via CRISPR/Cas9, resulting in temporary developmental malformations and permanent tail fin deformations in some adults.
- The study identifies Fndc3a as a novel regulator of epidermal cell properties, linking deficiencies in epidermal structure to impaired fin regeneration and shape in zebrafish.
Protease activable antifouling coatings based on peptide-poly(ethylene glycol) conjugates are shown. The material-specific adsorption of a bioconjugate is temporarily suppressed by extending a titanium binding sequence with a proteolytically cleavable epitope and a suitable interfering domain. The adsorption of the PEG-peptide conjugates onto titanium substrates can be regained by cleaving the interfering domain with Tobacco Etch Virus protease.
View Article and Find Full Text PDF(Bio)molecular surface patterning by phototriggered oxime ligation.
Angew Chem Int Ed Engl
September 2012
Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde, which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces with a fluoro marker and GRGSGR peptide, and can be imaged by time-of-flight secondary-ion mass spectrometry.
View Article and Find Full Text PDFPurpose: The present study investigates the suitability of computed tomography angiography (CTA) depicting the degree of renal artery stenosis for estimating renal blood flow (RBF) in a kidney.
Materials And Methods: We investigated renal artery stenosis assessment by CTA in eight adult female hybrid pigs with an ultrasound probe implanted at the renal vein for RBF measurement. An inflatable metal-free cuff was placed around the renal artery to control the RBF.
Aim: To evaluate for the first time in an animal model the possibility of absolute regional quantification of renal medullary and cortical perfusion by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a blood pool contrast agent.
Material And Methods: A total of 18 adult female pigs (age, 16-22 weeks; body weight, 45-65 kg; no dietary restrictions) were investigated by DCE-MRI. Absolute renal blood flow (RBF) measured by an ultrasound transit time flow probe around the renal vein was used as the standard of reference.