Circulating monocytes upregulate CD52 and sustain innate immune function in cirrhosis unless acute decompensation emerges.

Background & Aims: Infectious complications determine the prognosis of cirrhosis patients. Their infection susceptibility relates to the development of immuneparesis, a complex interplay of different immunosuppressive cells and soluble factors. Mechanisms underlying the dynamics of immuneparesis of innate immunity remain inconclusive.

The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses.

Adverse early-life experiences alter the regulation of major stress systems such as the hypothalamic-pituitary-adrenal (HPA) axis. Low early-life maternal care (MC) has repeatedly been related to blunted cortisol stress responses. Likewise, an acutely increased awareness of mortality (mortality salience [MS]) also has been shown to blunt cortisol responses.

Daily associations among sleep, posttraumatic stress disorder, and positive affect.

Research suggests a bidirectional association between sleep disturbances and posttraumatic stress disorder (PTSD) symptoms. However, most studies have been conducted with group-level data, which do not necessarily capture the associations between PTSD symptoms and sleep within an individual over time. This study aimed to add to the literature concerning the association between sleep and PTSD and extend these findings to investigate the effect of sleep disturbances on positive affect.

Establishment of permanent peritoneal PleurX catheter as palliative treatment of malignant ascites.

Introduction: Refractory malignant ascites (RMA) is a manifestation of end-stage cancer disease with a major impact on quality of life due to the symptom burden and need for repeated hospitalisations. We previously described the implantation of the permanent PleurX catheter as a treatment of RMA. The present study aimed to evaluate and describe our experience with the permanent PleurX catheter system in the largest cohort to date.