Lipid Nanoparticle Formulations for the Skin Delivery of Cannabidiol.

The aims of this work were to formulate cannabidiol in different lipid carriers for skin delivery after topical application and to study their stability, interaction with the skin, and antibacterial activity. Solid lipid nanoparticles and nanostructured lipid carriers loaded with cannabidiol were prepared and characterized in terms of their physicochemical properties, colloidal stability, protection of the antioxidant capacity of cannabidiol, as well as their retention over time. Skin penetration was assessed using an in vitro model with human skin.

Psychiatrists on forensic psychiatry after the law 81/2014 in Italy: findings from a national pilot survey.

After the approval of the law 81/2014, a new care-framework has been outlined for the psychiatric offenders in Italy and alternative facilities have been gradually activated. This pilot national survey was conducted in order to explore the attitudes of a panel composed by Italian psychiatrists, engaged in forensic not-engaged in forensic activities, on the changes related to the application of the law. We employed an ad-hoc questionnaire named SOPF: (in english: The Psychiatric Forensic Assessment after the Closing of the Forensic Psychiatric Hospitals) to explore the opinions regarding ten relevant issues in the field of forensic psychiatry and forensic assessment.

Intake Characteristics as Predictors of Psychotherapy Outcome in a Practice Research Network in Argentina.

There are few studies exploring intake diagnostic characteristics as predictors of change in integrative naturalistic settings. The aim of this study is to explore baseline variables at the intake process and establish the predictive value of the individual trajectories of the patients. We recruited 259 patients undergoing an integrative psychotherapy network of psychotherapists from Buenos Aires, Argentina.

Implementation of an Ecological Momentary Assessment (EMA) in Naturalistic Psychotherapy Settings: Qualitative Insights from Patients, Therapists, and Supervisors Perspectives.

Ecological momentary assessment (EMA) allows measuring intra-individual processes moment by moment, identifying and modeling, in a naturalistic way, individual levels and changes in different psychological processes. However, active EMA requires a high degree of adherence, as it implies a significant burden for patients. Moreover, there is still no consensus on standardized procedures for implementation.