Effect of an asthmatic attack on CD23 and CD21 expression on lymphocytes from allergic children during the allergen season.

Background: The overproduction of IgE antibodies by atopic individuals in response to inhaled aeroallergen, forms the basis of an allergic disease. Furthermore, the exposure to allergen might trigger the symptom exacerbation.

Objective: In children with bronchial asthma, the possible effects of seasonal, natural exposure to allergen on the expression of CD21 and CD23 antigens on B lymphocytes, and on the expression of HLA-DR, CD45RA and CD45RO on CD4+ T cells investigated.

CD21-CD23 ligand pair expression in children with allergic asthma.

The CD23 antigen, a low affinity receptor for IgE, was recently shown to interact with another ligand, CD21, and the pairing of these molecules is important in T cell-B cell interaction and control of IgE production. Here, we analysed the expression of CD21 and CD23 on CD4+ and CD20+ lymphocytes in 25 allergic children and 12 age-matched non-allergic controls. Both the percentage (P < 0.

Expression of lymphocytes Fc epsilon RII/CD23 in allergic children undergoing hyposensitization.

Owing to the proposed role of Fc epsilon RII/CD23 in allergic diseases, we analyzed the expression of this receptor on peripheral blood lymphocytes (pan-B, pan-T and CD4+ or CD8+ T cells) and its autoproteolytic product sCD23 in serum. This was done in 10 asthmatic children allergic to Dermatophagoides pteronyssinus (Dpt) before and 6 weeks after hyposensitization. FACS analysis of double, direct immunofluorescence staining of the whole blood revealed an elevated percentage of Fc epsilon RII/CD23+ lymphocytes in allergic children (10.