Publications by authors named "M McGrady"
Background: Coronary heart disease (CHD) remains a leading cause of mortality and disability worldwide. Approximately half of the patients who have had a prior hospital admission for CHD will have a recurrent coronary event, with the majority of these occurring within 12 months. Despite well-established evidence-based therapies, medication non-adherence is highly prevalent and reasons for medication non-adherence are poorly understood.
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- This study investigates the effectiveness of monetary incentives in improving adherence to obesity treatment among adolescents.
- Sixty adolescents were divided into three groups: Gain Group (GG) received rewards for achieving adherence goals, Loss Group (LG) lost funds for failing to meet goals, and Control Group (CG) received a fixed amount monthly.
- Results showed that the GG had significantly higher adherence scores and achieved more dietary reporting and step goals compared to the LG and CG, indicating that gain-framed incentives are more effective than loss-framed ones.
Article Synopsis
- Tissues are made up of units that can be studied at various scales, and new tech helps researchers analyze their structure and function in-depth.
- The article introduces a method called spatial cellular graph partitioning (SCGP) for automatically annotating tissue structures without manual input, making it more efficient.
- SCGP, along with its reference-query extension, shows strong accuracy in identifying tissue structures and offers valuable insights into diseases like diabetic kidney disease and skin disorders.
Article Synopsis
- Diabetic kidney disease (DKD) is a major cause of chronic kidney issues, and the understanding of its mechanisms in humans has lagged behind animal studies, impacting treatment development.
- The researchers employed a Spatial TissuE Proteomics (STEP) pipeline to analyze 21 proteins across various kidney tissue samples from healthy individuals and those with different stages of DKD, revealing specific patterns in protein expression and cellular composition.
- The study found significant changes in inflammatory cell presence and protein loss in the kidneys as DKD progressed, highlighting the utility of the STEP pipeline in understanding the disease's pathophysiology.
Objective: This meta-analysis examined the efficacy of adherence-promotion interventions for children, adolescents, and young adults prescribed a medication for > 90 days as part of a treatment regimen for a medical condition.
Methods: A systematic literature review was conducted to identify randomized controlled trials of adherence-promotion interventions published between 2013 and 2023 and including children, adolescents, and/or young adults with a medical condition. A total of 38 articles representing 39 trials met inclusion criteria.