Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease.

Antiretroviral therapy (ART) has decreased HIV-1 associated morbidity. However, despite ART, immune cells remain latently infected and slowly release viral proteins, leading to chronic inflammation and HIV-1 associated comorbidities. New strategies are needed to target viral proteins and inflammation.

Acute exposure to sublethal doses of neonicotinoid insecticides increases heat tolerance in honey bees.

The European honey bee, Apis mellifera L., is the single most valuable managed pollinator in the world. Poor colony health or unusually high colony losses of managed honey bees result from a myriad of stressors, which are more harmful in combination.

Fruit and vegetable intake among participants in a District of Columbia farmers' market incentive programme.

Objective: Limited research is available on whether participation in healthy food incentive programmes is associated with higher fruit and vegetable intake. The objective of the present study was to determine fruit and vegetable intake among participants in the Produce Plus Program, a farmers' market-based healthy food incentive programme in Washington, DC, and identify demographic and behavioural factors associated with higher fruit and vegetable intake.

Design: Using a cross-sectional survey, programme participants were interviewed at markets across DC between June and September 2015.

Performance assessment in health care providers: a critical review of evidence and current practice.

Aim: To evaluate methods of performance assessment through an international literature review and a survey of current practice.

Background: Over the past two decades health care organizations have focussed on promoting high quality care in conjunction with retaining motivated staff. Cognisant of such initiatives, we sought to evaluate assessment methods for qualified staff according to their utility in the working environment.

Multimedia software to help caregivers cope.

Objective: This report describes the design and evaluation of a software application to help carers cope when faced with caring problems and emergencies.

Design: The design process involved users at each stage to ensure the content of the software application was appropriate, and the research team carefully considered the requirements of disabled and elderly users.

Measurements: Focus group discussions and individual interviews were conducted in five European countries to ascertain the needs of caregivers in this area.