Nutrient availability in a freshwater-to-marine continuum: Cyanobacterial blooms along the Lake Okeechobee Waterway.

Water from the Lake Okeechobee watershed historically flowed south through the Everglades. Hydrologic alterations created the Lake Okeechobee Waterway, where lake water is periodically shunted east to the St. Lucie Estuary (C-44 canal) and west to the Caloosahatchee River and Estuary (C-43 canal).

Emerging evidence for pregnane steroid therapeutics for alcohol use disorders.

Many lines of research have suggested that the neuroactive pregnane steroids, including pregnenolone, progesterone, and allopregnanolone ([3α,5α]-3-hydroxypregnan-20-one, 3α,5α-THP), have therapeutic potential for treatment of alcohol use disorders (AUDs). In this chapter, we systematically address the preclinical and clinical evidence that supports this approach for AUD treatment, describe the underlying neurobiology of AUDs that are targeted by these treatments, and delineate how pregnane steroids may address various components of the disease. This review updates the theoretical framework for understanding how endogenous steroids that modulate the effects of alcohol, stress, excitatory/inhibitory and dopamine transmission, and the innate immune system appear to play a key role in the prevention and mitigation of AUDs.

Refining the implementation research logic model: a citation analysis, user survey, and scoping review protocol.

Introduction: The Implementation Research Logic Model (IRLM) aids users in combining, organizing, and specifying the relationships between important constructs in implementation research. The goal of the IRLM is to improve the rigor, reproducibility, and transparency of implementation research projects. The article describing the IRLM was published September 25, 2020 (, Vol 15); it has since been highly cited and included as a required element in multiple funding opportunity announcements from federal agencies.