Publications by authors named "M McElhiney"
As clinical genetic testing in the amyotrophic lateral sclerosis (ALS) diagnostic setting increases, the identification of at-risk family members has also expanded. No practice guidelines specifically for predictive genetic testing exist, and few studies about the psychological impacts of testing in this subgroup have occurred, limiting the ability to tailor recommendations and counseling in this community. We surveyed asymptomatic individuals at risk for inheriting an ALS-associated gene mutation.
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- Muscle cramps are a prevalent and disabling symptom in ALS, and there are currently no approved medications specifically for their treatment, prompting the investigation of the traditional Japanese medicine TJ-68.
- The trial aims to assess the safety and efficacy of TJ-68 in people with ALS suffering from frequent muscle cramps through a randomized, double-blind, and personalized N-of-1 design, involving 22 participants.
- The study will primarily evaluate TJ-68's safety while also measuring its effects on muscle cramp severity and overall quality of life using various scales and diaries over multiple treatment periods.
A theory-informed, rapid cycle approach to identifying and adapting strategies to promote sustainability: optimizing depression treatment in primary care clinics seeking to sustain collaborative care (The Transform DepCare Study).
Implement Sci Commun
January 2023
Background: Few real-world examples exist of how best to select and adapt implementation strategies that promote sustainability. We used a collaborative care (CC) use case to describe a novel, theory-informed, stakeholder engaged process for operationalizing strategies for sustainability using a behavioral lens.
Methods: Informed by the Dynamic Sustainability Framework, we applied the Behaviour Change Wheel to our prior mixed methods to identify key sustainability behaviors and determinants of sustainability before specifying corresponding intervention functions, behavior change techniques, and implementation strategies that would be acceptable, equitable and promote key tenets of sustainability (i.
Article Synopsis
- * Participants in the 25 mg group showed a significant reduction in depression scores after 3 weeks, with a mean change of -12.0, compared to -7.9 for 10 mg and -5.4 for the control group.
- * Although the higher dose showed benefits, many participants experienced adverse effects, including headache and nausea, and some reported suicidal thoughts, underscoring the need for further research.
Background: Despite improved health and during a strong job market (pre-COVID-19), a substantial proportion of HIV+ adults remained unemployed. This study sought to provide time-limited counseling to promote employment goals.
Objective: To determine whether behavioral activation (BA) or supportive counseling (SC), would be more effective in promoting vocational goals (full or part-time, paid or volunteer).