Publications by authors named "M McCullough"
Case-control studies of sun exposure and ultraviolet radiation (UVR) have consistently reported inverse associations with non-Hodgkin lymphoma (NHL) risk, but prospective studies have yielded mixed results. Few studies have explored these exposures in relation to multiple myeloma (MM) risk. To further evaluate these associations with NHL and MM risk and identify etiologically relevant exposure timing, we pooled data on 566,693 individuals from 6 United States (U.
View Article and Find Full Text PDFObjective: Our objective was to investigate the associations of sleep duration and weekend catch-up sleep with cancer risk among US adults in the Cancer Prevention Study-3.
Methods: Cancer Prevention Study-3 is a prospective cohort of approximately 250,000 US adults aged 30-65years. At baseline (2006-2013), participants were asked to report their average daily sleep duration over the past year for weekdays and weekends separately.
Animal models of thrombosis play a critical role in research, helping us understand the mechanisms of hemostasis and thrombus formation, as well as in the screening of anti-thrombotic drugs. This study aimed to evaluate the safety profile of two anticoagulants in murine research and to assess coagulation parameters, including prothrombin time (PT) and activated partial thromboplastin time (aPTT), using the VETSCAN VSpro coagulation analyzer in wild-type (C57BL/6) mice following administration of anticoagulants. Two experiments were conducted involving a total of sixty wild-type mice that received two common anticoagulants.
View Article and Find Full Text PDFBackground: Oral cancer remains a significant public health issue. General practitioners (GPs) can play an important role in raising awareness of oral cancer.
Objective: This paper explores why providing advice relating to modifiable risk behaviours associated with oral cancer and undertaking routine oral cancer screening are important for GPs in clinical practice.
Article Synopsis
- - The airway smooth muscle (ASM) cell's function in contraction and remodeling relies on changes in its cytoskeleton, shifting between a relaxed "fluid-like" state and a contractile "solid-like" state based on protein interactions.
- - The review explores the roles of various cytoskeletal components, such as actin and myosin, as well as factors that influence their behavior and how these interactions relate to the airway's extracellular matrix and the physical mechanics of airway movement.
- - The findings highlight new insights into the mechanisms of ASM cell activity, which could inform approaches to understanding and treating asthma-related airway obstruction.