Publications by authors named "M Mazzantini"
Article Synopsis
- Vitamin D deficiency is a significant public health issue in Europe, affecting not just the elderly but also those aged 50-70 years across both genders.
- A recent survey involving 870 subjects in Italy found that dietary vitamin D intake was alarmingly low, with average daily intakes of 5.05 μg for females and 6.25 μg for males, which is below the recommended average.
- The data revealed a trend where vitamin D intake decreases with age, indicating that older adults are particularly at risk for potential hypovitaminosis due to inadequate dietary consumption.
Article Synopsis
- Atypical femoral fractures (AFFs) are rare but serious injuries linked to bisphosphonate use, and understanding their incidence and risk factors is crucial for treatment.
- A study reviewed radiographs of femoral fractures in patients over 60 to identify cases of AFFs, finding a 10% occurrence in their sample, an increase from a previous study's 5%.
- While bisphosphonates are effective for preventing osteoporotic fractures, prolonged use may lead to an increased risk of AFFs, especially at specific sites of the femur.
Osteoporosis is a skeletal disease characterised by reduced bone mass and deterioration of bone microarchitecture, underlying a higher risk of fragility fractures. Several options are available for its treatment, including both anti-resorptive and anabolic agents. The present review discusses and summarises the most recent literature on anabolic treatment, with a focus on abaloparatide, and on the assessment of fragility fracture risk, with a focus on trabecular bone score.
View Article and Find Full Text PDFOsteoporosis is a worldwide common disease characterised by reduced bone mass and increased risk of fractures.Many genetic variants are associated with the disease, but they account for only a small percentage of variance in individual bone mineral density and fragility fracture risk. Only recently have researchers recognised the role of a broad variety of environmental factors in the pathogenesis of osteoporosis, which has led to a further step: how genetic and environmental factors can interact, which is the next frontier in research on bone fragility.
View Article and Find Full Text PDFEvaluating adherence, tolerability and safety of oral calcium citrate in elderly osteopenic subjects: a real-life non-interventional, prospective, multicenter study.
Aging Clin Exp Res
February 2024
Background: Osteoporosis is a common concern in the elderly that leads to fragile bones. Calcium supplementation plays a crucial role in improving bone health, reducing fracture risk, and supporting overall skeletal strength in this vulnerable population. However, there is conflicting evidence on the safety of calcium supplements in elderly individuals.
View Article and Find Full Text PDF