Publications by authors named "M Maynes"

Article Synopsis
  • Measuring deeply virtual Compton scattering (DVCS) on the neutron is essential for understanding the nucleon's structure through generalized parton distributions (GPDs).
  • Neutron targets help complement data obtained from polarized protons, particularly in determining the poorly understood GPD E, which is crucial for analyzing quark contributions to nucleon spin.
  • The experiment utilized a longitudinally polarized electron beam at Jefferson Lab and the CLAS12 detector to measure DVCS on the neutron for the first time, providing new insights into quark-flavor separation of relevant Compton form factors.
View Article and Find Full Text PDF

Microglial calcium signaling is rare in a baseline state but strongly engaged during early epilepsy development. The mechanism(s) governing microglial calcium signaling are not known. By developing an in vivo uridine diphosphate (UDP) fluorescent sensor, GRAB, we discovered that UDP release is a conserved response to seizures and excitotoxicity across brain regions.

View Article and Find Full Text PDF

HIV cure still remains an elusive target. The "Shock and Kill" strategy which aims to reactivate HIV from latently infected cells and subsequently kill them through virally induced apoptosis or immune mediated clearance, is the subject of widespread investigation. NF-κB is a ubiquitous transcription factor which serves as a point of confluence for a number of intracellular signaling pathways and is also a crucial regulator of HIV transcription.

View Article and Find Full Text PDF

The contribution of circulating verses tissue resident memory T cells (TRMs) to clinical neuropathology is an enduring question due to a lack of mechanistic insights. The prevailing view is TRMs are protective against pathogens in the brain. However, the extent to which antigen-specific TRMs induce neuropathology upon reactivation is understudied.

View Article and Find Full Text PDF

Background: Achieving a functional or sterilizing cure for HIV will require identification of therapeutic interventions that reduce HIV reservoir size in infected individuals. Proteasome inhibitors, such as ixazomib, impact multiple aspects of HIV biology including latency, transcription initiation, viral replication, and infected cell killing through the HIV protease - Casp8p41 pathway, resulting in latency reversal and reduced measures of HIV reservoir size ex vivo.

Methods: We conducted a phase 1b/2a dose escalating, open label trial of weekly oral ixazomib for 24 weeks in antiretroviral (ART)-suppressed, HIV positive adults (NCT02946047).

View Article and Find Full Text PDF