Publications by authors named "M Matta"
Lipoprotein (a) [Lp(a)] is a lipoprotein with multiple deleterious characteristics and is a recognized cardiovascular (CV) risk factor. The pro-atherogenic, pro-thrombotic, and pro-inflammatory features of Lp(a) are associated not only with atherosclerotic vascular disease but also with aortic valve calcification and all-cause mortality. One of the most interesting aspects of Lp(a) is that its level is determined by genetics in more than 90% of cases, with lifestyle habits having very little influence.
View Article and Find Full Text PDFDiagnosed and Nondisclosed Concussions Among Young Athletes With ADHD.
Arch Clin Neuropsychol
November 2024
Objective: Within a sample of young athletes with attention-deficit/hyperactivity disorder (ADHD), to explore the frequency of disclosed and nondisclosed concussions, identify reasons the youth did not report a suspected concussion, and learn the frequency that the youth still practiced or played in a game after a suspected concussion.
Method: Cross-sectional surveys were completed by 448 youth athletes (ages 8-14 years) and a corresponding parent (or caregiver). As part of larger respective surveys, questions regarding ADHD status and concussion history were asked of the youth and parents.
Article Synopsis
- Tacrolimus capsules contain an amorphous form of the drug, and this study focused on how varying levels of crystallinity affect the drug's performance after oral dosing.
- The researchers tested tacrolimus products with crystallinity levels of 20% and 50%, finding that both levels failed to meet bioequivalence criteria when compared to an amorphous generic and the reference drug, Prograf®.
- The study concluded that the crystallization of tacrolimus in generic formulations can significantly alter pharmacokinetics, particularly affecting maximum blood concentration (C) values and raising potential clinical concerns.
Background: Routinely collected electronic healthcare records (EHRs) document many details of a person's health, including demographics, preventive services, symptoms, tests, disease diagnoses and prescriptions. Although not collected for research purposes, these data provide a wealth of information which can be incorporated into epidemiological investigations, and records can be analysed to understand a range of important health questions. We aimed to understand the use of routinely collected health data in epidemiological studies relating to three of the most common chronic respiratory conditions, namely: asthma, chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD).
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