Publications by authors named "M Matas"
Introduction: Thoracic myelopathy in neuro fibromatosis-1 (NF-1) is most commonly due to intra-spinal neurofibromas/dumb-bell tumors/intra-canal rib head penetration (RHP) causing cord compression. However, acute thoracic myelopathy due to rapid progression of the kyphoscoliotic curve alone in NF-1 without a significant spinal cord compression occurs very rarely. This case report discusses our experience with one such patient and we also discuss intraoperative and post-operative challenges encountered with this patient and a rare complication of hemothorax postoperatively.
View Article and Find Full Text PDFCorrection to: Domperidone nanocrystals with boosted oral bioavailability: fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction.
Stalielson Tatenda Ndlovu Naseem Ullah Shahzeb Khan Pritika Ramharack Mahmoud Soliman Marcel de Matas
Drug Deliv Transl Res
April 2024
Article Synopsis
- Rivaroxaban is a direct factor Xa inhibitor and part of a drug class known as direct oral anticoagulants (DOACs), which serve as alternatives to traditional blood thinners like warfarin.
- Despite their popularity, variability in how different individuals respond to DOACs can lead to ineffective treatment or adverse effects such as bleeding or blood clots.
- A study involving 60 healthy volunteers explored the influence of factors like food intake, sex, biogeographical background, and genetic variations on the metabolism of rivaroxaban, revealing that those with slow NAT2 acetylation had notable changes in drug levels, suggesting a need for further research on genetic impacts on rivaroxaban's effectiveness.
Article Synopsis
- Amlodipine is an antihypertensive drug, and this study explored genetic factors affecting its pharmacokinetics and safety through a candidate gene approach with data from 160 volunteers.
- Poor metabolizers of the CYP2D6 gene had a longer drug half-life, while a specific genotype (rs34059508 G/A) was linked to increased drug exposure and potential side effects like thoracic pain and dizziness.
- This research is the first to establish these genetic associations with amlodipine, indicating a need for further studies before clinical use.