Publications by authors named "M Masuya"
Colorectal cancer (CRC) resulting from chronic inflammation is a crucial issue in patients with inflammatory bowel disease (IBD). Although many reports established that intestinal resident CX3CR1 macrophages play an essential role in suppressing intestinal inflammation, their function in colitis-related CRC remains unclear. In this study, we found that colonic CX3CR1 macrophages, which were positive for MHC-II, F4/80 and CD319, promoted colitis-associated CRC.
View Article and Find Full Text PDFArticle Synopsis
- Genotoxic stress in hematopoietic stem and progenitor cells (HSPCs) leads to varied patterns of malignant transformation, with a specific focus on a vulnerable subpopulation of long-term repopulating HSCs that are affected by MLL-ENL.
- The study identified the Bahcc1 gene, associated with trimethylated histone modifications and noted for its high expression in acute myeloid leukemia (AML) with poor outcomes, as a key factor in susceptibility to leukemic transformation.
- Findings suggest a potential therapeutic target through the MLL-fusion-Bahcc1 interaction, highlighting the importance of Bahcc1 in both the progression of MLL-rearranged AML
Article Synopsis
- - The traditional view of hematopoiesis as a stepwise process has shifted to a continuous one due to advancements in single-cell RNA sequencing, which revealed complexities in the differentiation process that weren’t previously acknowledged.
- - This study focuses on the B-plasmacytoid dendritic cell (pDC) pathway, identifying significant fluctuations in transcriptome dynamics in the B/NK progenitor region using novel computational methods that model splicing kinetics.
- - The findings illustrate that these fluctuations are critical for differentiation, demonstrating a model that reconciles continuous and discrete processes, with implications for understanding other developmental systems.
Background: Although platelets, which contain large amounts of phospholipids, play an important role in blood coagulation, there is still no routine assay to examine the effects of platelets in blood coagulation.
Methods: Hemostatic abnormalities in patients with thrombocytopenia, including those with idiopathic thrombocytopenic purpura (ITP), were examined using clot wave analysis (CWA)-small-amount tissue-factor-induced FIX activation (sTF/FIXa) and thrombin time (TT).
Results: Although there were no marked differences in the three parameters of activated partial thromboplastin time (APTT) between normal healthy volunteers and typical patients with ITP, the peak heights of the CWA-sTF/FIXa were markedly low in patients with ITP.