Publications by authors named "M Mascitti"
Deepening Cisplatin sensitivity on Oral Squamous cell Carcinoma cell lines after PON2 knockdown: A FTIRM investigation.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Cisplatin is a platinum-based chemotherapy drug with antimicrobial and antitumoral activity, largely used for a long time in the treatment of several cancers, including the Oral Squamous Cell Carcinoma (OSCC), which is one of the most frequent neoplasms of the oral cavity. Due to its aggressiveness and metastatic invasion, OSCC is characterized by poor outcome, often related also to chemoresistance mechanisms. The intracellular enzyme paraoxonase-2 (PON2) normally acts defending cells from the damages induced by Reactive Oxygen Species.
View Article and Find Full Text PDFTo evaluate the advantages of dual-energy computed tomography (DECT) virtual non-hydroxyapatite color mapping (VNHAP) in combination with standard bone CT (BCT) in the identification of subtle or occult traumatic fractures referred to emergency and acceptance departments (DEAs). Forty patients (22 men; mean age 83 ± 23.7 y) with suspected traumatic fractures referred to our emergency department and examined with a fast kilovoltage-switching single-source spectral CT scan between January and October 2023 were retrospectively reviewed.
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- Robotic surgery has shifted urology towards minimally invasive techniques, significantly benefiting procedures like radical prostatectomy.
- A review of literature on robotic platforms reveals that while the DaVinci system is predominant, new alternatives are emerging, but comprehensive comparisons are rare.
- The role of artificial intelligence in robotic surgery is growing, suggesting that more research is needed to fully understand its impact and future developments in urology.
Article Synopsis
- Renal cell carcinoma (RCC) consists of various subtypes with unique genetic changes, requiring tailored treatment approaches for each.
- A detailed review was performed of English language articles on the molecular mechanisms of kidney cancer, excluding non-original studies.
- Hereditary kidney cancer accounts for 5-8% of cases, linked to specific syndromes with genetic mutations that lead to tumor development and related symptoms, emphasizing the importance of understanding these mechanisms for early diagnosis and treatment options.
High resolution analysis of collagen bundles could provide information on tumor onset and evolution. This study was focused on the microarchitecture and biomolecular organization of collagen bundles in oral tongue squamous cell carcinoma (OTSCC). Thirty-five OTSCC biopsy samples were analyzed by synchrotron-based phase-contrast microcomputed tomography and Fourier transform infrared imaging (FTIRI) spectroscopy.
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