LC-OCT for early diagnosis and characterization of dermatologic adverse events to oncologic drugs and correlation to histopathology.

Background: Targeted and immune therapies have recently been associated with the occurrence of multiple cutaneous toxicities, often challenging to differentiate by clinical examination alone without histology. Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive and innovative imaging technique that has been shown to be almost as effective as histology in diagnosing several skin conditions. Our study aimed to assess the effectiveness of LC-OCT in predicting the clinical evolution of early maculopapular eruptions related to antineoplastic targeted therapy and immunotherapy.

Self-Consciousness as a Construction All the Way Down.

Contemporary mind and brain sciences provide theories and data that seem to confirm a hypothesis about human nature that we might formulate as follows. Human life is conditioned by a need that is no less important than elementary biological needs (such as survival and reproduction) or universal forms of social competition: the need to build and, indeed, defend a whose solidity and clarity are the foundation of our intra- and inter-personal equilibrium and therefore of psychological well-being and mental health. In this article, distancing ourselves from a neo-Cartesian position still prevalent in the philosophy of mind and approaching instead the outcomes of contemporary cognitive sciences, we sketch the complex interweaving of the cognitive, emotional, and affective elements that are constitutive of subjective identity, with a focus on the role played in self-identity construction by Theory-of-Mind abilities.

Real-world experience with fluocinolone acetonide intravitreal implant in patients with diabetic macular edema.

Objectives: to evaluate long-term effectiveness and safety of fluocinolone acetonide (FAc) implant used as second-line treatment in patients with persistent diabetic macular edema (DME).

Methods: retrospective data chart review of 241 pseudophakic eyes of 178 patients treated with FAc from July 2017 to December 2021 in 10 medical retinal units in Italy. The primary endpoint was the change of best-corrected visual acuity (BCVA) and central macular thickness (CMT) at 2 years.