Publications by authors named "M Markowski"
Nest fumigation behavior involves the incorporation of fresh green plant fragments that contain ectoparasite-repellent volatile compounds into birds' nests. This behavior is relatively rare among bird species, and there is ongoing debate about whether it benefits parental breeding success. In this study, we experimentally tested whether the inclusion of aromatic-herbal plant fragments in the nests of great tits affects the physiological condition of nestlings, as indicated by blood levels of hematocrit, hemoglobin, glucose, and body condition indices, such as weight and wing length.
View Article and Find Full Text PDFIntroduction: Non-castrating therapies are an unmet clinical need for patients with advanced prostate cancer. To maximize quality of life and prioritize cardiovascular health, we investigated SGLT2 inhibitors as a non-castrating therapy in patients with prostate cancer.
Materials And Methods: We conducted a retrospective analysis of patients with either local or biochemically recurrent prostate cancer who initiated therapy with an SGLT2 inhibitor without concurrent androgen deprivation therapy.
Background And Objective: Owing to the expansion of treatment options for metastatic hormone-sensitive prostate cancer (mHSPC) and an appreciation of clinical subgroups with differential prognosis and treatment responses, prognostic and predictive biomarkers are needed to personalize care in this setting. Our aim was to evaluate a multimodal artificial intelligence (MMAI) biomarker for prognostic ability in mHSPC.
Methods: We used data from the phase 3 CHAARTED trial; 456/790 patients with mHSPC had evaluable digital histopathology images and requisite clinical variables to generate MMAI scores for inclusion in our analysis.
Article Synopsis
- Eating and drinking are essential for life, but older patients often face restrictions due to concerns about aspiration; EDAR provides a way to uphold their comfort and autonomy despite these risks.
- A qualitative study involving healthcare professionals from Japan and the UK explored their experiences and decision-making processes regarding EDAR, resulting in three key themes: healthcare systems, priorities in decision-making, and patient-family relationships.
- Findings revealed similarities and differences between the two countries’ approaches, showing that cultural dynamics heavily influence how decisions are made, particularly in Japan, where there is a tendency to prioritize family wishes over clinical judgment.
Article Synopsis
- Renal cell carcinoma (RCC) is a prevalent kidney cancer, and PSMA is a protein found in high levels in certain tumors, including metastatic RCC. This study investigates the effectiveness of PSMA-based imaging and treatment in preclinical models of RCC.
- Researchers developed a PSMA-overexpressing murine cell line and used advanced imaging techniques (PET/CT and PET/MR) to assess the accumulation and treatment potential of tailored radiotheranostic agents (Ga-L1, Lu-L1, and Ac-L1) specifically targeting cancerous cells.
- Results showed significantly higher uptake of the PSMA-targeted agents in cancerous cells compared to normal cells, indicating the specificity of these