Relationship of Age and Running Biomechanics in Female Recreational Runners.

Middle-age and older runners demonstrate differences in running biomechanics compared with younger runners. Female runners demonstrate differences in running biomechanics compared with males, and females experience hormonal changes during menopause that may also affect age-related changes in running biomechanics. The purpose of this study was to determine the relationship between age and running biomechanics in healthy female recreational runners.

Self-other distinction modulates the sense of self-agency during joint actions.

In daily life interactions, we achieve goals with partners through tight temporal coordination or sequential joint efforts. Is our individual sense of control over shared outcomes (sense of self-agency) the same as the one experienced when we act alone? Do we explicitly and implicitly feel like we are fully in control of the motor act even if the goal is finally achieved by our partner? To address these questions, we measured explicit and implicit sense of self-agency in individual and (coordinated or sequential) interactive contexts. We studied 42 healthy adult participants during active/passive button presses aimed at turning on a light bulb.

Association between higher glucose levels and reduced survival in patients with non-small cell lung cancer treated with immune checkpoint inhibitors.

Background: Obesity and hypercholesterolemia have been associated with better responses to ICIs in NSCLC, while type 2 diabetes (T2D) has been associated with a worse response. However, the association between glucose levels and outcomes remains unknown. This study investigated the impact of mean baseline glucose levels, T2D, dyslipidemia, and obesity on overall survival (OS) in NSCLC patients undergoing ICI therapy.

Calcium Cross-Linked Cellulose Nanofibrils: Hydrogel Design for Local and Controlled Nitric Oxide Release.

Nitric oxide (NO) holds promise for wound healing due to its antimicrobial properties and role in promoting vasodilation and tissue regeneration. The local delivery of NO to target cells or organs offers significant potential in numerous biomedical applications, especially when NO donors are integrated into nontoxic viscous matrices. This study presents the development of robust cellulose nanofibril (CNF) hydrogels designed to control the release of nitric oxide (NO) generated from a NO-donor molecule (-nitrosoglutathione, GSNO) obtained from the nitrosation of its precursor molecule glutathione (GSH).