Publications by authors named "M Margalit"
Background: Dynamic changes in non-invasive tests, such as changes in alanine aminotransferase (ALT) and MRI proton-density-fat-fraction (MRI-PDFF), may help to detect metabolic dysfunction-associated steatohepatitis (MASH) resolution, but a combination of non-invasive tests may be more accurate than either alone. We developed a novel non-invasive score, the MASH Resolution Index, to detect the histological resolution of MASH.
Methods: This study included a derivation cohort of 95 well-characterised adult participants (67% female) with biopsy-confirmed MASH who underwent contemporaneous laboratory testing, MRI-PDFF and liver biopsy at two time points.
Article Synopsis
- A clinical study evaluated the effects of pegozafermin, a new therapy, on patients with nonalcoholic steatohepatitis (NASH) and fibrosis to meet an important medical need.
- The study involved adults with specific criteria receiving weekly doses for 20 weeks, measuring improvements in liver condition and safety.
- Results showed significant improvements in liver health and metabolic factors, with most participants tolerating the treatment well, although some experienced mild adverse effects.