Publications by authors named "M Mare"
Background: The retromolar canal (RMC) is an anatomical structure of the mandibular bone located distal to the last molar. The frequency of anatomical variation in human anatomy is approximately 30-35%. This study aimed to evaluate the prevalence of the retromolar canal in a population subjected to cone beam computed tomography (CBCT).
View Article and Find Full Text PDFAT-rich interaction domain 1 () is a pivotal gene with a significant role in gastrointestinal tumors which encodes a protein referred to as BAF250a or SMARCF1, an integral component of the SWI/SNF (SWItch/sucrose non-fermentable) chromatin remodeling complex. This complex is instrumental in regulating gene expression by modifying the structure of chromatin to affect the accessibility of DNA. Mutations in have been identified in various gastrointestinal cancers, including colorectal, gastric, and pancreatic cancers.
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View Article and Find Full Text PDFArticle Synopsis
- - The Hippo pathway, first found in fruit flies, is crucial for regulating tissue health and organ growth, with YAP and TAZ being key players in controlling cell behavior.
- - Dysregulation of Hippo signaling is common in gastrointestinal cancers, and abnormal activation of YAP/TAZ is linked to chronic inflammation that may lead to cancer development.
- - More research is needed to understand how disruptions in Hippo signaling contribute to cancer initiation, which could help in creating new early treatment options targeting this pathway.