Publications by authors named "M Manzoni"
Introduction: Surgery is still the main line of treatment for papillary thyroid cancer (PTC) with a current trend for de-intensified treatment based on an excellent prognosis. The role of a routine prophylactic central neck dissection (PCND) is still debated as its impact on oncologic outcomes has never been cleared by a randomized clinical trial. In this study, we aimed to report our long-standing experience in PCND and its potential contemporary role in the treatment of PTC.
View Article and Find Full Text PDFBackground: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease that affects approximately one in 500 people. Cardiac magnetic resonance (CMR) imaging has emerged as a powerful tool for the non-invasive assessment of HCM. CMR can accurately quantify the extent and distribution of hypertrophy, assess the presence and severity of myocardial fibrosis, and detect associated abnormalities.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on colorectal cancer (CRC) with the BRAF V600E mutation, which is linked to poor patient outcomes and resistance to treatment, prompting a network meta-analysis to identify the best treatment options.
- Researchers systematically searched medical databases for studies involving patients with BRAF-mutated CRC who received first-line chemotherapy and analyzed survival data using hazard ratios (HRs).
- Results indicated that standard chemotherapy doublets, either alone or with bevacizumab, did not significantly improve overall survival (OS) or progression-free survival (PFS) compared to other treatment options, with the combination therapy showing the highest effectiveness score.
Background: The escalating prevalence of diabetes, with its multifaceted complications, poses a pressing challenge for healthcare systems globally. In response, the advent of continuous glucose monitoring (CGM) systems, offering technological solutions for daily diabetes management, presents significant opportunities. However, the widespread adoption faces several barriers, linked both to the technological configuration of the devices and to the psychological dimension of patients.
View Article and Find Full Text PDFBackground: The COVID-19 pandemic substantially affected the lives of persons with inherited neuromuscular disorders (INMD), causing disruption in clinical and support services. While several studies have investigated mental health, distress and psychosocial resources in the general population during the pandemic, little is known about the experience of persons with INMD.
Methods: This study was aimed to fill this gap by jointly investigating both psychopathological symptoms and psychosocial resources - specifically, resilience and perceived social support - among persons with INMD during the pandemic, taking into account demographic and clinical factors.