Publications by authors named "M Manthou"
The skin, the largest organ of the human body, plays numerous essential roles, including protection against environmental hazards and the regulation of body temperature. The processes of skin homeostasis and ageing are complex and influenced by many factors, with epigenetic mechanisms being particularly significant. Epigenetics refers to the regulation of gene expression without altering the underlying DNA sequence.
View Article and Find Full Text PDFThe current case report presents the postmortem examination findings of a 17-week-old female fetus displaying thanatophoric dysplasia type 1 (TD-1) due to a known fibroblast growth factor receptor 3 (FGFR3) gene mutation. Gross and X-ray examination revealed significant abnormalities, including skeletal malformations with prominent TD-1 femur curvature. Microscopical evaluation indicated inadequate histological growth for the gestational age, with specific organ immaturity noted in multiple hematoxylin and eosin sections from internal organs, bone from epiphyses and diaphyses levels.
View Article and Find Full Text PDFInfertility is a global phenomenon that impacts people of both the male and the female sex; it is related to multiple factors affecting an individual's overall systemic health. Recently, investigators have been using mesenchymal stem cell (MSC) therapy for female-fertility-related disorders such as polycystic ovarian syndrome (PCOS), premature ovarian failure (POF), endometriosis, preeclampsia, and Asherman syndrome (AS). Studies have shown promising results, indicating that MSCs can enhance ovarian function and restore fertility for affected individuals.
View Article and Find Full Text PDFArticle Synopsis
- Skin is the largest organ in the body and serves essential functions like protection, temperature regulation, sensation, and immune defense.
- Its development begins in the embryonic stage, regulated by various molecular signals that guide the formation of the epidermis, hair follicles, and sweat glands.
- Understanding the molecular mechanisms behind skin development and disease can lead to new targeted therapies and personalized treatments for skin disorders.
Article Synopsis
- - Skin stem cells (SCs) are essential for maintaining and regenerating skin tissue, with different types located in various skin regions like the epidermis and sweat glands.
- - Their development begins during embryogenesis from multipotent SCs, and they remain ready to respond to skin repair needs throughout adulthood, influenced by molecular cues for quiescence, self-renewal, and differentiation.
- - Disruptions in the balance of these cues can lead to issues like skin cancer and poor wound healing, prompting research into the molecular mechanisms behind SC behavior for potential regenerative medicine applications.