Publications by authors named "M Mannes"
Article Synopsis
- Sepsis is a serious condition that poses risks to human health and has significant economic implications; recent research highlights various factors, including cellular senescence, that contribute to this issue.
- In an experimental study on male mice, sepsis was induced via cecal ligation and puncture, leading to noticeable pulmonary damage and increased markers associated with acute lung injury and cellular senescence.
- The results revealed complex changes in senescence-related pathways, suggesting that while some markers decrease, others may increase during the early stages, pointing to the need for further research on the long-term impacts of sepsis on multiple organ systems.
Acute injuries trigger an intense activation of the body's defense mechanisms aiming to limit damage and initiate healing. Among the crucial components of the intravascular immune system, the complement system plays a significant role in traumatic injuries, albeit often negatively. It has been suggested that excessive activation of the complement system, transitioning from a localized and timed response to a systemic one, can lead to a loss of its host-protective characteristics.
View Article and Find Full Text PDFThe introduction of a therapeutic anti-C5 antibody into clinical practice in 2007 inspired a surge into the development of complement-targeted therapies. This has led to the recent approval of a C3 inhibitory peptide, an antibody directed against C1s and a full pipeline of several complement inhibitors in preclinical and clinical development. However, no inhibitor is available that efficiently inhibits all three complement initiation pathways and targets host cell surface markers as well as complement opsonins.
View Article and Find Full Text PDFMelanocortin 4 receptor (MC4-R) antagonists are actively sought for treating cancer cachexia. We determined the structures of complexes with and . These peptides differ from by substituting His with Pro and inserting Gly or Arg.
View Article and Find Full Text PDFSoluble terminal complement complex blood levels are elevated in schizophrenia.
Eur Arch Psychiatry Clin Neurosci
August 2024
Article Synopsis
- - The study investigated the complement system's role in unmedicated schizophrenia patients by measuring complement activation products before and after treatment, comparing results to matched controls.
- - While no significant differences in C5a, C4, or classical pathway function were found between patients and controls, plasma levels of the terminal complement complex (sTCC) were significantly higher in patients, indicating potential chronic immune activation.
- - The elevated sTCC levels were associated with C-reactive protein, suggesting sTCC could serve as a trait marker for immune response in schizophrenia; further research is recommended to track immune changes over time in early psychosis cases.