Wasp Venom: Future Breakthrough in Production of Antimicrobial Peptides.

The emergence of multi-drug-resistant pathogens and the decrease in the discovery of newer antibiotics have led to a quest for novel alternatives. Recently, wasp venom has spiked interest due to the presence of various active compounds, showcasing a diverse range of therapeutic effects. Wasps are creatures of the Hymenoptera order, and their venom chemically comprises antimicrobial peptides such as Anoplin, Mastoparan, Polybia-CP, Polydim-I, and Polybia MP1 that play a significant role in the biological effects of the venom.

Recent progress and prospects in the organocatalytic Morita-Baylis-Hillman reaction.

The organocatalytic asymmetric Morita-Baylis-Hillman (MBH) reaction produces a significant carbon-carbon bond formation that involves the addition of α,β-unsaturated carbonyl compounds to activated alkenes to give α-methylene-β-hydroxycarbonyl compounds. Commercially available starting materials, excellent atom economy, mild reaction conditions, and flexible products are the major highlights of this method. In this review, we discuss the recent developments in the organocatalytic MBH reaction, covering literature from 2018 to 2023.