Publications by authors named "M Malmsten"
Combining functionalities-nanoarchitectonics for combatting bacterial infection.
Adv Colloid Interface Sci
December 2024
New antimicrobial and anti-inflammatory therapeutics are needed because of antibiotic resistance development and resulting complications such as inflammation, ultimately leading to septic shock. The antimicrobial effects of various nanoparticles (NPs) are currently attracting intensive research interest. Although various NPs display potent antimicrobial effects against strains resistant to conventional antibiotics, the therapeutic use of such materials is restricted by poor selectivity between bacteria and human cells, leading to adverse side effects.
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- Peptides are being explored as alternative treatments for various infections, but their effectiveness is limited by issues like instability and toxicity to healthy cells.
- New administration methods, particularly using nanoparticles as carriers, show promise for improving peptide delivery, though current design efforts are time-consuming and often based on trial and error.
- Recent advancements in computational approaches aim to speed up the creation of efficient drug delivery systems for peptides, increasing the potential for optimized drug development.
In this study, we report the degradation of smooth and rough lipopolysaccharides (LPS) from Gram-negative bacteria and of lipoteichoic acid (LTA) from Gram-positive bacteria by peptide-coated TiO nanoparticles (TiO NPs). While bare TiO NPs displayed minor binding to both LPS and LTA, coating TiO NPs with the antimicrobial peptide LL-37 dramatically increased the level of binding to both LPS and LTA, decorating these uniformly. Importantly, peptide coating did not suppress reactive oxygen species generation of TiO NPs; hence, UV illumination triggered pronounced degradation of LPS and LTA by peptide-coated TiO NPs.
View Article and Find Full Text PDFStimuli-responsive drug delivery systems for inflammatory skin conditions.
Acta Biomater
October 2024
Inflammatory skin conditions highly influence the quality of life of the patients suffering from these disorders. Symptoms include red, itchy and painful skin lesions, which are visible to the rest of the world, causing stigmatization and a significantly lower mental health of the patients. Treatment options are often unsatisfactory, as they suffer from either low patient adherence or the risk of severe side effects.
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- This study looks at how certain antimicrobial peptides (AMPs) can help make tiny titanium dioxide (TiO) particles better at fighting germs when they're exposed to light.
- The researchers found that some versions of the AMP, like EFK17-W, stick better to the TiO particles and are more effective against bacteria, especially when combined with the particles.
- However, these peptides didn’t change how the TiO particles created reactive oxygen species (ROS), which are important for killing bacteria, and the coatings lasted even after being exposed to UV light.