Publications by authors named "M Mally"

Background: Breast cancer is the leading cause of cancer-related death among women worldwide. Mortality from breast cancer can be reduced through early detection and prevention. Despite the availability of breast cancer screening methods, the uptake of screening services remains very low, especially in low-resource countries like Tanzania.

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Microbial plant pathogens secrete a range of effector proteins that damage host plants and consequently constrain global food production. Necrosis and ethylene-inducing peptide 1-like proteins (NLPs) are produced by numerous phytopathogenic microbes that cause important crop diseases. Many NLPs are cytolytic, causing cell death and tissue necrosis by disrupting the plant plasma membrane.

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Article Synopsis
  • Antibodies that target TNF-alpha are commonly used for treating inflammatory bowel disease, but many patients do not respond to them, leading researchers to investigate how glycosylation patterns could influence their effectiveness.
  • The study focused on different glycosylation forms of the anti-TNF-alpha antibody adalimumab, specifically looking at variations in fucose and sialic acid content, and assessed their impact on immune cells called monocyte-derived dendritic cells (mo-DCs).
  • The results revealed that glycosylation variations did not affect how well the antibodies were taken up by mo-DCs or alter the immune markers on these cells, although one glycosylated form did influence certain cytokine levels.
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Polysialic acid (polySia) is a posttranslational modification found on only a handful of proteins in the central nervous and immune systems. The addition of polySia to therapeutic proteins improves pharmacokinetics and reduces immunogenicity. To date, polysialylation of therapeutic proteins has only been achieved in vitro by chemical or chemoenzymatic strategies.

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Capnocytophaga canimorsus is a dog's and cat's oral commensal which can cause fatal human infections upon bites or scratches. Infections mainly start with flu-like symptoms but can rapidly evolve in fatal septicaemia with a mortality as high as 40%. Here we present the discovery of a polysaccharide capsule (CPS) at the surface of C.

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