Publications by authors named "M Malloy"
Background: The genetic basis of hypertriglyceridemia (HTG) is complex and includes variants in Lipase Maturation Factor 1 (LMF1), an endoplasmic reticulum (ER)-chaperone involved in the post-translational activation of lipoprotein lipase (LPL).
Objective: The objective of this study was to identify and functionally characterize biallelic LMF1 variants in patients with HTG.
Methods: Genomic DNA sequencing was used to identify biallelic LMF1 variants in HTG patients without deleterious variants in LPL, apolipoprotein C-II (APOC2), glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) or apolipoprotein A-V (APOA5).
Optimization of Smoking Classification by Applying Neural Network with Variable Importance Using Cytokine Biomarkers.
Proc (Int Conf Comput Sci Comput Intell)
December 2023
Cigarette smoking is a preventable epidemic that is a leading cause of death. It increases the risk of coronary heart disease, stroke, lung cancer, chronic obstructive lung diseases etc., multifold.
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- The study analyzed central line-associated bloodstream infections (CLABSI) in adult ICUs in Victoria, Australia, over 11 years, focusing on incidence rates, pathogens, and antimicrobial resistance.
- A total of 608 CLABSI events were reported, showing a significant decline in incidence from 1.39 to 0.70 per 1,000 central-line days, while the most common pathogen identified was coagulase-negative Staphylococci, with a 69.0% increase in infections caused by this organism.
- Despite the overall decrease in CLABSI, the study noted a stable trend in antimicrobial resistance rates, with a decrease in MRSA and increases in vancomycin and ceftriaxone-resistant pathogens,
Logistic Regression and Statistical Regularization Techniques for Risk Classification of Coronary Artery Disease using Cytokines transported by high density lipoproteins.
Proc (Int Conf Comput Sci Comput Intell)
December 2023
Coronary artery disease (CAD) is a leading cause of mortality in the world. It is important to be able to proactively assess the risk of the disease, using novel biomarkers like cytokines that are indicators of inflammation in addition to traditional predictors of risk. Atherosclerosis, the primary cause of CAD, is an inflammatory disease involving cytokines.
View Article and Find Full Text PDFSmoking Classification Using Novel Plasma Cytokines by implementing Machine Learning and Statistical Methods.
Proc (Int Conf Comput Sci Comput Intell)
December 2023
Smoking is a major cause of premature and preventable death. Tobacco exposure has a detrimental effect on many organs and contributes to multiple diseases including chronic obstructive pulmonary disease (COPD), cardiovascular disease, cancer, and diabetes. Cytokines are inflammatory biomarkers that are mechanistically associated with smoking.
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