Green Synthesis and Characterization of Silver Nanoparticles from Leaf Extract: Evaluation of Their Antioxidant, Anti-Inflammatory, Antibacterial, and Antibiofilm Efficacies.

The use of metal nanoparticles is gaining popularity owing to their low cost and high efficacy. We focused on green synthesis of silver nanoparticles (AgNPs) using (Tc) leaf extracts. The structural characteristics of Tc nanoparticles (TcAgNPs) were determined using several advanced techniques.

Palmitic acid alters enhancers/super-enhancers near inflammatory and efferocytosis-associated genes in human monocytes.

Free fatty acids like palmitic acid (PA) are elevated in obesity and diabetes and dysregulate monocyte and macrophage functions, contributing to enhanced inflammation in these cardiometabolic diseases. Epigenetic mechanisms regulating enhancer functions play key roles in inflammatory gene expression, but their role in PA-induced monocyte/macrophage dysfunction is unknown. We found that PA treatment altered the epigenetic landscape of enhancers and super-enhancers (SEs) in human monocytes.

Accuracy and Reliability of Oral Exfoliative Cytology in Age Estimation: An Observational Study.

Aim And Objectives: Age and gender identification are critical in forensic investigations, especially for unidentified human bodies. This study explores differences in nuclear size, nuclear area, and nuclear-cytoplasmic ratio between healthy individuals and those with physiological or pathological conditions, aiming to understand how these variations may influence age estimation.

Materials And Methods: Following ethical clearance, the study was conducted on 80 participants aged 20-35 years, who were divided into four groups of 20 each, Group 1: Healthy individuals; Group 2: Individuals with physiological variations; Group 3: Individuals with pathological variations; and Group 4: Individuals with acquired conditions.

Chronic Adaptations of the Ulnar Nerve in Professional Baseball Pitchers: Ulnar Nerve Adaptations in Pitchers.

Context: Screening programs to identify negative ulnar nerve adaptations in throwing athletes can help minimize injury risk and individualize treatment programs prior to the onset of symptoms. However, it is currently unclear how the ulnar nerve structurally adapts chronically in professional baseball pitchers. Objective: To compare ulnar nerve ultrasound structural characteristics between the throwing (dominant) and non-throwing control (non-dominant) elbows in professional pitchers, with a secondary purpose of comparing ultrasound structural characteristics between subluxating and non-subluxating ulnar nerves.

Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge cf. Collected in the Bismarck Sea.

Sponges of the genus are known for the production of a large diversity of bioactive metabolites. Contignasterines A () and B () were isolated as major metabolites of the sponge cf. collected in the Bismarck Sea along with the known and highly bioactive steroid contignasterol () possessing a similar oxidized aglycone.