Publications by authors named "M Maleki"
Differential effects of β-hydroxybutyrate and α-ketoglutarate on HCT-116 colorectal cancer cell viability under normoxic and hypoxic low-glucose conditions: exploring the role of SRC, HIF1α, ACAT1, and SIRT2 genes.
Mol Genet Genomics
January 2025
Recent therapeutic strategies have highlighted the potential of β-hydroxybutyrate (BHB) and α-ketoglutarate (α-KG) as effective anticancer agents, particularly for colon cancer. These metabolites can modulate cellular metabolism and induce epigenetic changes, inhibiting tumor growth. Nonetheless, certain cancer cells may utilize ketone bodies, like BHB as nutrient sources under hypoxic conditions, potentially reducing treatment efficacy.
View Article and Find Full Text PDFAims: This study investigates the differences in patient demographics and outcomes between teaching and non-teaching hospitals in Iran. By analyzing these differences, it aims to provide useful information for policymakers to optimize resource allocation, improve patient care, and balance educational and service delivery goals in teaching hospitals.
Materials And Methods: In this cross-sectional investigation, both teaching and non-teaching general hospitals were examined.
Article Synopsis
- Thousands of young adults experience traumatic brachial plexus injuries (TBPIs), which often result in permanent disabilities and difficulties returning to work, creating social and economic challenges.
- The study aims to assess return-to-work rates after TBPI and compare outcomes between healthcare systems in Germany, Serbia, and the UK.
- Preliminary findings suggest that about 60% of TBPI patients manage to return to work, but often in different occupational roles, indicating ongoing challenges in patient reintegration despite variations in healthcare support.
A Half-century Experience of Running Journal Clubs and applying Interactive Teaching-learning Methods at Orthopedic Department of Tehran University of Medical Sciences.
Arch Bone Jt Surg
January 2024
Journal club is crucial in medical professions education, especially residency training. Critical evaluation allows learners to read, understand, and apply the evidence to bridge the gap between research and practice. Academic members of the Tehran University of Medical Sciences (TUMS) Orthopedic Department have held about 2,300 weekly sessions for around 50 years, even in times of crises, to review the latest publications in orthopedics and sometimes linked their journal clubs to hospitalized cases.
View Article and Find Full Text PDFBackground: Biventricular dysfunction is frequent in patients with repaired tetralogy of Fallot, necessitating routine imaging to monitor for worsening conditions and determine whether procedures like pulmonary valve replacement (PVR) are needed. This study aimed to highlight the parameters of cardiac magnetic resonance imaging (CMR) and their association with adverse outcomes in the midterm follow-up of these patients.
Methods: This longitudinal study recruited all patients with a history of tetralogy of Fallot total correction (TFTC) who had two CMR images at a minimum three-month interval at Rajaie Center from 2007 through 2017.