Efficacy and safety of subcutaneous abatacept + standard treatment for active idiopathic inflammatory myopathy: phase III randomised controlled trial.

Objective: To evaluate the efficacy and safety of subcutaneous (SC) abatacept and standard of care (SOC) for the treatment of idiopathic inflammatory myopathy (IIM) over 52 weeks.

Methods: In this randomised, double-blind, placebo-controlled phase III trial, patients with treatment-refractory IIM received SC abatacept (125 mg weekly) + SOC (abatacept group) or placebo + SOC (placebo group) (NCT02971683). A 24-week double-blind period was followed by an open-label period to assess outcomes from continued therapy with abatacept and initiation with abatacept (placebo-to-abatacept switch group) from 24 to 52 weeks.

Nitrogen isotopes reveal high NO emissions from arid agricultural soils in the Salton Sea Air Basin.

Air quality management commonly aims to mitigate nitrogen oxide (NO) emissions from combustion, reducing ozone (O) and particulate matter (PM) pollution. Despite such ongoing efforts, regulations have recently proven ineffective in rural areas like the Salton Sea Air Basin of Southern California, which routinely violates O and PM air quality standards. With over $2 billion in annual agricultural sales and low population density, air quality in the region is likely influenced by the year-round farming activity.

A social norms campaign based positive intervention aimed at promoting protective behaviours.

Introduction: Social norms campaigns are communication strategies designed to influence people's behaviour by highlighting the social norms of their reference group. Such campaigns have been shown to be effective in promoting healthy behaviours in a variety of settings. This study explored the effectiveness of a social norms campaign applied to COVID-19 protective behaviours among university students during the pandemic.

Mental health care-seeking and barriers: a cross-sectional study of an urban Latinx community.

Background: The Latinx community faces an increasing amount of mental health challenges and disparities in care. While the contributing factors are complex, there are likely potential barriers related to connecting with mental health support and accessing care that can be addressed.

Methods: To investigate barriers in connecting to mental health care, we conducted a cross-sectional survey of mental health service use and barriers in an urban community with a primarily Hispanic/Latinx ethnicity using a modified random walk approach for door-to-door data collection with a two-cluster sampling frame.

The Vaginal Penetration Skills Scale (VPSS): a paradigm shift in genito-pelvic pain/penetration disorder screening, assessment, and stratification.

Background: Receptive vaginal penetration skills have been implicated in the etiology, explanatory models, and treatment of genito-pelvic pain penetration disorder (GPPPD). However, there are no psychometric skills measures designed to screen, assess, and stratify GPPPD.

Aim: We aimed to develop and psychometrically evaluate a new scale-the Vaginal Penetration Skills Scale (VPSS)-to screen, assess, and stratify GPPPD.