Publications by authors named "M Malcov"
Purpose: The trend of delaying childbirth has resulted in a growing number of advanced-aged women who are opting for preimplantation genetic testing (PGT) to screen for monogenic diseases or structural chromosomal rearrangements (PGT-M and PGT-SR). This increase in demand necessitates the development of a clinical predictive model for live birth outcomes in these women. Therefore, the objective of this study is to construct a comprehensive predictive model that assesses the likelihood of achieving a successful live birth in advanced-aged women undergoing PGT-M and PGT-SR treatments.
View Article and Find Full Text PDFBackground: Population genetic carrier screening (PGCS) for cystic fibrosis (CF) has been offered to couples in Israel since 1999 and was included in a fully subsidized national program in 2008. We evaluated the impact of PGCS on CF incidence, genetic and clinical features.
Methods: This was a retrospective national study.
Quantitative and qualitative spermatogenic impairments are major causes of men's infertility. Although fertilization (IVF) is effective, some couples persistently fail to conceive. To identify causal variants in patients with severe male infertility factor and repeated IVF failures, we sequenced the exome of two consanguineous family members who underwent several failed IVF cycles and were diagnosed with low sperm count and motility.
View Article and Find Full Text PDFPurpose: Women carriers of FMR1 premutation are at increased risk of early ovarian dysfunction and even premature ovarian insufficiency. The aim of this study was to examine a possible association between FMR1 permutation and numeric sex chromosome variations.
Methods: A retrospective case-control study conducted in the reproductive center of a university-affiliated medical center.
The impact of fragile X premutation carrier status on embryo morphokinetic development.
Reprod Biomed Online
November 2022
Article Synopsis
- The study investigates how inheriting the FMR1 premutation allele affects embryo development during IVF.
- The analysis involved 529 embryos from 126 IVF cycles, comparing morphokinetic development and quality between embryos with the FMR1 allele and those with a normal allele.
- While no significant differences were found in early morphokinetic parameters, FMR1 embryos experienced delayed blastulation and a lower rate of top-quality embryos compared to normal embryos.