Publications by authors named "M Makenzie Beaman"

Article Synopsis
  • Scientists studied how tick bites affect skin to understand diseases caused by ticks.
  • They found many genes that behaved differently in skin right after a tick bite compared to skin taken later, showing how the body reacts over time.
  • The research could help identify markers to predict how a person will respond to tick bites and help with treatments in the future.
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Autism spectrum disorder (ASD) is a complex neurodevelopmental disability that negatively affects children's learning, motor behavior, social communication, and interaction. It was estimated that, in 2020, 1 in 36 children aged 8 years in the United States had ASD. Caring for children with ASD might exert significant psychological and emotional distress on parents.

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Oculogastrointestinal neurodevelopmental syndrome has been described in seven previously published individuals who harbor biallelic pathogenic variants in the CAPN15 gene. Biallelic missense variants have been reported to demonstrate a phenotype of eye abnormalities and developmental delay, while biallelic loss of function variants exhibit phenotypes including microcephaly and craniofacial abnormalities, cardiac and genitourinary malformations, and abnormal neurologic activity. We report six individuals from three unrelated families harboring biallelic deleterious variants in CAPN15 with phenotypes overlapping those previously described for this disorder.

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Article Synopsis
  • - The study investigates how adverse childhood experiences (ACEs) may affect Brain Derived Neurotrophic Factor (BDNF) levels, which are important for brain development and memory, to understand long-term health impacts.
  • - A systematic review and meta-analysis of 22 studies found no significant difference in BDNF levels between children exposed to ACEs and those unexposed, suggesting more research is needed in this area.
  • - The research highlighted that factors like the age of subjects, type of biological sample collected, and classification of ACEs lead to variability in findings, indicating that these elements should be carefully considered in future studies.
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