[Preparation and structural determination of lyotropic lamellar liquid crystalline systems of pharmaceutical importance]].

Lamellar lyotropic liquid crystalline systems are thermodynamically stable, optically isotropic continuous compositions composed of particles of a few nanometeres in diameter which are formed spontaneously or with a low energy input in the definite proportions of the given components [8, 27]. New possibilities for the development of controlled drug delivery systems are inherent in these systems in consequence of their stability and special, skin friendly structure [3]. The present aim was to formulate and study two- or multicomponent compositions with a relatively low surfactant content, composed of materials official in the pharmacopoeia and suitable for therapeutic purposes.

Structure and drug release of lamellar liquid crystals containing glycerol.

Lamellar lyotropic liquid crystalline (LLC) systems are thermodynamically stable, optically isotropic systems, which are formed with low energy input. New possibilities for the development of controlled drug delivery systems are inherent in these systems due to their stability and special skin-similarly structure. The present aim was to formulate multicomponent LLC systems with a relatively low surfactant content, composed of materials official in the European Pharmacopoeia 4th.