Cyclopia-otocephaly association: a new case of the most severe variant of agnathia-holoprosencephaly complex.

This report describes a new case of true cyclopia with otocephaly and additional brain malformations (alobar holoprosencephaly). This is a very rare occurrence involving lack of cleavage of the prosencephalon and disturbed development of the first branchial arch. An inductive defect of the prechordal mesoderm is considered as the cause for this malformation, which is a part of agnathia-holoprosencephaly complex.

Prenatal diagnosis of type III congenital cystic adenomatoid malformation of the lung.

The authors report a case of type III Congenital Cystic Adenomatoid Malformation (CCAM) of the lung in a stillborn with ultrasound and pathological findings. CCAM is an unusual morphological entity and the solid pattern (type III) is the rarest. Antenatal demonstration may allow to salvage these infants by surgical removal in immediate postnatal period.

[Morphological study of the removed fetus after therapeutic abortion for echographic anomalies (apropos of 42 cases)].

In 42 cases, fetal abnormalities were diagnosed by obstetric ultrasonography and the pregnancy was terminated. The malformations included: anencephaly (22), severe hydrocephaly (4, one with a spina bifida), encephalocele and meningocele (2) amniotic band syndrome (4; a correct prenatal diagnosis was performed during the second trimester in two cases), major anterior abdominal wall defects (2), Pena-Shokeir syndrome type I? (I), severe renal abnormalities (2), conjoined twins, dicephalus type (2), cystic hygroma and hydrops fetalis (2), osteogenesis imperfecta, type II (I). Thus, there were 23 fetuses with a polygenetically determined status; five fetuses could be affected by an autosomal recessive disorder.