Publications by authors named "M Maietti"
Article Synopsis
- Extracellular vesicles (EVs) are lipid bilayer particles released by cells, and circulating EVs (cEVs) may serve as important biomarkers for diagnosing and monitoring tumors, although effective isolation methods for clinical use are still needed.
- A new procedure using bench centrifuge techniques was developed to isolate serum cEVs from small blood samples, allowing detailed characterization of these vesicles including their size, quantity, and nucleic acid content.
- This procedure effectively identified specific EVs related to multiple myeloma, providing a way to differentiate between cancer patients and healthy subjects, and can enhance real-time tumor monitoring with minimal invasiveness and ease of use.
Natural killer (NK) cell neoplasms are characterized by clonal proliferation of cytotoxic NK cells. Since there is no standard treatment to date, new therapeutic options are needed, especially for NK aggressive tumors. Fyn tyrosine kinase has a key role in different biological processes, such as cell growth and differentiation, being also involved in the pathogenesis of hematologic malignancies.
View Article and Find Full Text PDFMany cell types release extracellular vesicles (EVs), including exosomes, microvesicles (MVs), and apoptotic bodies, which play a role in physiology and diseases. Presence and phenotype of circulating EVs in hematological malignancies (HMs) remain largely unexplored.The aim of this study was to characterize EVs in peripheral blood of HM patients compared to healthy subjects (controls).
View Article and Find Full Text PDFProtease activity in fractionated blood cells of the vanadium accumulating ascidian Phallusia mammillata.
Comp Biochem Physiol A Mol Integr Physiol
April 2000
Proteolytic activity was studied in the fractionated blood cells of the vanadium accumulating ascidian P. mammillata by separating the cells before measuring their activity. Cells were separated to avoid vanadocyte breakdown and subsequent vanadium diffusion into the assay medium.
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