Publications by authors named "M Magiorkinis"
Article Synopsis
- HIV-1 has three main groups and 11 subtypes, with various circulating recombinant forms (CRFs) causing widespread epidemics.
- A specific subtype known as CRF04_cpx was identified in Cyprus and Greece, composed of genetic material from subtypes A and G along with unclassified sections.
- The genetic analysis of CRF04_cpx revealed a complex, mosaic structure incorporating sequences from at least five subtypes (A, G, H, K, and unclassified regions), illustrating HIV-1's ability to recombine and create diverse strains.
Recombination is one of several factors contributing to the genetic diversity of HIV-1, which is divided into group M (itself comprising 11 subtypes, A-K) and two other groups named O and N. In the present study, the full-length genome of an HIV-1 isolate obtained from a Greek subject (GR17) infected in the Democratic Republic of the Congo (formerly Zaire) was analyzed to reveal a novel mosaic sequence composed of subtypes A, G, and E and regions of indeterminate classification. In particular, most of pol and tat/vpu, as well as the region encoding intracellular domain of gp41, did not cluster with any of the previously characterized HIV-1 subtypes.
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