Effect of Plasma Treatment on Coating Adhesion and Tensile Strength in Uncoated and Coated Rubber Under Aging.

The degradation of rubber materials under environmental and mechanical stress presents a significant challenge, particularly due to UV (ultraviolet light) exposure, which severely impacts the material's physical properties. This study aims to enhance the UV stability and longevity of rubber by evaluating the performance of modified polyurethane and silicone coatings as protective stabilizers. Natural rubber-styrene-butadiene rubber (NR-SBR), known for its exceptional mechanical properties, was selected as the base material.

Factoring fu Variability Into Estimates of Unbound Drug Concentrations Negatively Biases the MIC Versus % Probability of Target Attainment Relationship of Antimicrobial Agents.

The clinical breakpoint for a drug-pathogen combination reflects the drug susceptibility of the pathogen wild-type population, the location of the infection, the integrity of the host immune response, and the drug-pathogen pharmacokinetic (PK)/pharmacodynamic (PD) relationship. That PK/PD relationship, along with the population variability in drug exposure, is used to determine the probability of target attainment (PTA) of the PK/PD index at a specified minimum inhibitory concentration (MIC) for a selected target value. The PTA is used to identify the pharmacodynamic cutoff value (CO), which is one of the three components used to establish the clinical breakpoint.

Evaluation of spp. System Model Against .

Cereal crops are affected by one of the most devastating diseases worldwide, known as Fusarium head blight (FHB), with being the most isolated causal pathogen. Another species associated with this disease is . This species has been considered a relatively weak pathogen compared to , but its importance has increased due to its occurrence in cereal grains worldwide.

Acceptability and Future Considerations for Telegenetic Counseling After the COVID Pandemic: Interviews with Genetic Counselors, Clinicians, and Patients.

While telegenetic counseling has increased substantially since the start of the COVID-19 pandemic, previous studies reported concerns around building rapport, nonverbal communication, and the patient-counselor relationship. This qualitative evaluation elicited feedback from genetic counselors, referring clinicians, and patients from a single healthcare organization to understand the user-driven reasons for overall satisfaction and experience. We conducted 22 in-depth, semi-structured interviews with participants from all 3 groups between February 2022 and February 2023.

Design and Process Considerations for Preparation of Modified Release Ivermectin and Praziquantel Tablets by Wet Granulation.

Dosage forms containing Ivermectin (IVER) and Praziquantel (PRAZ) are important combination drug products in animal health. Understanding the relationship between products with differing in vitro release characteristics and bioequivalence could facilitate generics. The goal of this study was to create granulations for each active ingredient, with similar release mechanisms, but substantially different in vitro release rates, and then compressing these granulations into tablets with differing release rates.