Publications by authors named "M Maffia"
Anaplastic thyroid carcinoma (ATC) ranks among the most lethal human cancers. Increased migratory and invasive capabilities are critical in malignancy and are often secondary to epithelial-mesenchymal transition (EMT). However, it is not clear whether the invasive behavior of ATC is associated with the presence of EMT.
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- AI platforms are important tools in genetics and medicine, helping to analyze lots of patient data and find new diseases.
- They are making it possible to better understand complex health issues and improve treatments for things like rare diseases and cancers.
- These technologies are helping doctors make better decisions for patient care, leading to more personalized and effective treatments.
Article Synopsis
- * The TME presents obstacles like physical barriers and signals that hinder T cell effectiveness, but combining ACT with treatments like chemotherapy, radiotherapy, and checkpoint inhibitors may enhance outcomes.
- * Advanced technologies allow for strategies that could improve ACT success, including optimizing T cell movement to tumors, adapting their metabolism for better function, and engineering T cells with synthetic receptors for enhanced survival.
Osteoarthritis (OA) stands as a prevalent and progressively debilitating clinical condition globally, impacting joint structures and leading to their gradual deterioration through inflammatory mechanisms. While both non-modifiable and modifiable factors contribute to its onset, numerous aspects of OA pathophysiology remain elusive despite considerable research strides. Presently, diagnosis heavily relies on clinician expertise and meticulous differential diagnosis to exclude other joint-affecting conditions.
View Article and Find Full Text PDFParkinson's disease (PD) is a prevalent neurodegenerative disorder, primarily associated with dopaminergic neuron depletion in the Substantia Nigra. Current treatment focuses on compensating for dopamine (DA) deficiency, but the blood-brain barrier (BBB) poses challenges for effective drug delivery. Using differentiated SH-SY5Y cells, we investigated the co-administration of DA and the antioxidant Grape Seed Extract (GSE) to study the cytobiocompability, the cytoprotection against the neurotoxin Rotenone, and their antioxidant effects.
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