Publications by authors named "M Maddah"
The 12-lead electrocardiogram (ECG) is inexpensive and widely available. Whether conditions across the human disease landscape can be detected using the ECG is unclear. We developed a deep learning denoising autoencoder and systematically evaluated associations between ECG encodings and ~1,600 Phecode-based diseases in three datasets separate from model development, and meta-analyzed the results.
View Article and Find Full Text PDFLanthanide nitride (N) materials have garnered significant interest in recent years due to their promising potential as heterogeneous catalysts for green ammonia synthesis under low temperature and pressure reaction conditions. Here, we report on the synthesis of an extended series of lanthanide () nitride powders ( = lanthanum, cerium, neodymium, samarium, gadolinium, terbium, dysprosium, erbium, lutetium) and their structural and vibrational properties. Polycrystalline powders were fabricated using a ball milling mechanochemical process, and their structural properties were assessed by X-ray diffraction (XRD) and transmission electron microscopy (TEM).
View Article and Find Full Text PDFArticle Synopsis
- Medical record review by physician committees is the current standard for identifying cardiovascular outcomes in clinical trials, but it's time-consuming and inconsistent.
- A new AI model called "HF-NLP" was developed to automatically assess heart failure outcomes, tested on data from international trials, including the DELIVER trial.
- The AI achieved 83% agreement with expert committee decisions, and when supplemented with human reviews for uncertain cases, it could reach 91% agreement while significantly reducing workload.
Article Synopsis
- Prostate cancer, a common cancer in men, is influenced by various factors including age, genetics, and lifestyle, with mutations in the TP53 gene linked to poor patient outcomes.
- Research shows that men with TP53 mutations have significantly lower overall survival rates and faster disease progression compared to those without these mutations.
- Monitoring TP53 mutations is important in managing prostate cancer treatment, as they indicate a higher risk of death and disease progression.
Article Synopsis
- Achieving at least 150 minutes of moderate-to-vigorous physical activity weekly lowers the risk of cardiovascular events and is a key public health goal, but the impact of different activity patterns (like "weekend warrior" vs. regular) on disease incidence is unclear.
- A study involving 89,573 UK Biobank participants who wore accelerometers found that both weekend warriors and those who engage in regular physical activity had significantly lower risks of developing various diseases compared to inactive individuals.
- Stronger protective effects were noted for cardiometabolic conditions, with the weekend warrior pattern showing lower risks for hypertension, diabetes, obesity, and sleep apnea, indicating the health benefits of any physical activity, even if concentrated on weekends.