Methotrexate in the treatment of mycosis fungoides - a multicenter observational study in 79 patients.

Objective: The first report concerning methotrexate (MTX) in the treatment of Mycosis fungoides (MF) was published in 1964 by Wright. The mechanism of MTX action in the treatment of primary cutaneous T-cell lymphoma (CTCL) has been not explained in detail yet (the anti-inflammatory, immunomodulating, immunosuppressive, and cytostatic actions have been under discussion).

Patients And Methods: This is a retrospective analysis of 79 MF patients in 4 dermatology clinical centers in Poland.

Oncogenic BRAF mutations and p16 expression in melanocytic nevi and melanoma in the Polish population.

Introduction: Twenty-five - fifty percent of skin melanomas arise from nevi. Melanocyte proliferation is activated by , then is arrested, but single nevi transform to melanomas. p16 controls arrest, and p16 loss may promote transformation.

Febrile neutropenia in a metastatic melanoma patient treated with ipilimumab - case report.

Background: Ipilimumab is a fully human monoclonal antibody (mAb) targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4). Ipilimumab is currently approved in the U.S.

Resistance to vemurafenib can be reversible after treatment interruption: a case report of a metastatic melanoma patient.

About 40% to 60% of melanomas present BRAF mutation. Selective BRAF inhibitors such as vemurafenib and dabrafenib are currently approved for the treatment of advanced melanoma patients with BRAF mutation. The treatment-induced tumor regression occurs in the majority of patients; however, acquired resistance to BRAF inhibitors is observed in most of the patients after 6 to 7 months.

Skin pH is lower in type 1 diabetes subjects and is related to glycemic control of the disease.

Background: Diabetes is a systemic disease affecting many organs, including skin. Skin may reflect the condition of internal organs. The aim of our study was to measure skin pH in type 1 diabetes mellitus (T1DM) patients and in healthy controls and to evaluate the association between metabolic control of diabetes and skin acidity in T1DM patients.