Publications by authors named "M Machado-Neves"
Eugenol has pharmacological properties, but its impact on renal function is limitedly studied. Thus, this study evaluated the effects of eugenol at 10, 20, and 40 mg kg, administered via gavage for 60 days, on histological, biochemical, oxidative, and proteomic parameters in rat kidneys. Adult Wistar rats treated with 10 mg kg of eugenol had kidneys with low total antioxidant capacity, high nitric oxide content, and high percentual of blood vessels, with no damage to renal function or morphology.
View Article and Find Full Text PDFArsenic in drinking water has been associated with an increased risk of health concerns. This metalloid is ingested and distributed throughout the body, accumulating in several organs, including the testis. In this organ, arsenic disturbs steroidogenesis and spermatogenesis and affects male fertility.
View Article and Find Full Text PDFAtrazine is an herbicide widely used on plantations worldwide. Experimental studies suggest that the herbicide impairs male reproductive function in mammals. This systematic review and meta-analysis aimed to evaluate the impact of atrazine exposure on the levels of hormones from the hypothalamic-pituitary-testicular axis using murine as the animal model.
View Article and Find Full Text PDFArticle Synopsis
- - Endometritis is a major factor causing subfertility in mares, and studying the uterine fluid's protein composition can help improve understanding and treatment of the condition.
- - The research involved analyzing the protein profiles of uterine fluid from healthy mares and those with different types of endometritis, revealing 549 detectable proteins and focusing on 279 common to all groups.
- - Significant differences were found in protein abundance between healthy mares and those with infections or post-breeding endometritis, leading to insights on potential biomarkers for diagnosis and treatment of the disease.
Combined exercise hinders the progression of pulmonary and right heart harmful remodeling in monocrotaline-induced pulmonary arterial hypertension.
J Appl Physiol (1985)
January 2025
Article Synopsis
- The study investigated whether combined moderate-intensity exercise could slow down harmful changes in the lungs and right heart in rats with pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT).
- Rats underwent a 3-week exercise program including aerobic and resistance training, which improved their physical endurance and prevented negative changes in pulmonary artery resistance and right ventricular function.
- The exercise also helped maintain heart cell function, reduced structural damage to the right ventricle and lungs, and lowered oxidative stress levels associated with PAH.