Publications by authors named "M Maccioni"
Article Synopsis
- The study investigates cellular immunity responses against SARS-CoV-2 among patients in Córdoba, Argentina, during two distinct waves of the pandemic that featured different viral variants and social behavior.
- Findings reveal a disruption in lymphocyte populations, specifically noting an increase in B cells and a decrease in CD3 T cells compared to healthy donors, with a more significant reduction in Tregs among severe cases.
- Results suggest a potential new biomarker, the CD8/CD8 index, for predicting disease progression, as it correlated with increased severity while also showing altered effector cytokine production in T cell populations.
The range of vaccines developed against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) provides a unique opportunity to study immunization across different platforms. In a single-center cohort, we analyzed the humoral and cellular immune compartments following five coronavirus disease 2019 (COVID-19) vaccines spanning three technologies (adenoviral, mRNA and inactivated virus) administered in 16 combinations. For adenoviral and inactivated-virus vaccines, heterologous combinations were generally more immunogenic compared to homologous regimens.
View Article and Find Full Text PDFThe increasing penetration of distributed generation (DG) across power distribution networks (DNs) is forcing distribution system operators (DSOs) to improve the voltage regulation capabilities of the system. The increase in power flows due to the installation of renewable plants in unexpected zones of the distribution grid can affect the voltage profile, even causing interruptions at the secondary substations (SSs) with the voltage limit violation. At the same time, widespread cyberattacks across critical infrastructure raise new challenges in security and reliability for DSOs.
View Article and Find Full Text PDFDifferent cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities.
Front Immunol
February 2023
Article Synopsis
- This study investigates the effects of cytokine storms in COVID-19 patients from Córdoba, Argentina, comparing data from the first two waves of the pandemic to understand links between demographics, comorbidities, and disease outcomes.
- Results showed that patients during the second wave were younger and had fewer comorbidities, with distinct cytokine and chemokine profiles, while pre-existing conditions did not significantly impact cytokine levels.
- The research identified specific inflammatory markers, such as IL-6 and C-reactive protein, that could help predict patient outcomes, particularly differentiating between mortality and recovery during the first wave of infections.
Oral squamous cell carcinoma (OSCC) is one of the most frequent types of oral cancer in developing countries and its burden correlates with exposure to tobacco and excessive alcohol consumption. Toll like receptors (TLRs) are major sensors of inflammatory stimuli, from both microbial and sterile causes and as such, they have been related to tumor progression and metastasis. Here, we evaluated the expression of TLR2, 4 and 9 as well as CD3+, CD8+ and Granzyme B+ cell infiltration by immunohistochemistry in oral samples of 30 patients with OSCC, classified according to their consumption of alcohol.
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