[Pharmacy counselling and antiretroviral therapy compliance: a patient survey].

All patients must be in position to take advantage of advances in pharmaceutical therapy as well as information on their treatment when medicine-taking scheme are complex and/or undesirable effects are expected. That is why in 1996 we set up a pharmacy consultation carried out by staff specially trained for it. The two objectives of this study are, on the one hand, to assess the patient's compliance and also their knowledge on the medical prescription with the help of a questionnaire and on the other hand, to check the implementation by the staff of our procedures (handing over medicine-taking scheme whenever there has been a change in the patient's treatment).

Failure of traditional trough levels to predict tacrolimus concentrations.

The objective of this study was to estimate tacrolimus population parameter values and to evaluate the ability of the maximum a posteriori probability (MAP) Bayesian fitting procedure to predict tacrolimus blood levels, using the traditional strategy of monitoring only trough levels, for dosage individualization in liver transplant patients. Forty patients treated with tacrolimus after liver transplantation were studied during the early posttransplant phase (first 2 weeks). This phase was divided into four time periods (1-4 days, 5-7 days, 8-11 days, 12-14 days).