Publications by authors named "M MacLaughlin"
Article Synopsis
- Scientists created new medicines called spectinamides to help treat tuberculosis (TB) more effectively.
- One of these, named MBX-4888A, works well with other TB drugs like rifampin and pyrazinamide in mice.
- The research showed that using MBX-4888A can help shorten the treatment time for TB and seems to be safe for long-term use in mice.
Article Synopsis
- Spectinamides are new medicines that help fight TB (tuberculosis), modified to work better in the body.
- In studies with mice, one type called MBX-4888A showed it could improve treatment when used with other TB drugs.
- This research tested how well it works in different mouse models, showing it's safe and might help cure TB faster.
Two samples of adult daily smokers completed a structured interview to determine nicotine dependence according to generic (DSM-IV/ICD-10), Fagerström [Fagerström Tolerance Questionnaire (FTQ), Fagerström Test for Nicotine Dependence (FTND), Heavy Smoking Index (HSI), and time to first cigarette after awakening (TFC)], consumption [e.g., cigarettes/day (CPD)], and self-rating (e.
View Article and Find Full Text PDFBSP/Bilirubin binding protein (BBBP) is a protein located on the sinusoidal membrane of the liver that transport several organic anions. The aim of this investigation was to determine whether BBBP is present in the kidney and its role in p-aminohippurate transport (PAH). Anti-BBBP antibodies inhibited PAH uptake in brush border membrane vesicles (BBMV) and Na(+)-independent PAH uptake in basolateral membrane vesicles (BLMV).
View Article and Find Full Text PDFAbstinence from smoking increases blood levels of caffeine and may potentiate the ability of caffeine to increase anxiety, insomnia, etc., during smoking cessation. The present study tested this hypothesis using a wider range of abstinence levels (0, 36 and 84 h), caffeine doses (0, 200 and 400 mg) and subjective effects (31 measures) than prior studies.
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