Publications by authors named "M MASSIMO"

Introduction: The increase in the average age of the population has resulted in a greater focus on interventions designed to facilitate successful Ageing. Notwithstanding its potential, the strategy of the board game remains relatively underexplored. This study aims to ascertain its role in fostering older people's well-being.

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A metanalysis of available randomized controlled trials and observational studies comparing self-expanding (SE) and balloon-expandable (BE) bioprostheses in patients with small aortic annulus and aortic stenosis for short- and midterm hemodynamic and clinical outcomes was performed. A total of 21 studies with a total 8,647 patients (SE: n = 4,336 patients vs BE: n = 4,311 patients) were included. SE bioprostheses had a lower postoperative mean gradient at 30 days (Mean Difference [MD] -5.

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Article Synopsis
  • This study looked at 51 patients with relapsed/refractory large B-cell lymphomas who did not respond to CAR T-cell therapies axicabtagene ciloleucel or tisagenlecleucel and assessed the effectiveness of salvage therapies.
  • Among these patients, 43% were treated in clinical trials with promising treatments like glofitamab and loncastuximab tesirine, while others received standard therapies like lenalidomide and chemotherapy.
  • The findings indicated that high levels of circulating tumor DNA (ctDNA) were linked to worse patient outcomes, with an overall 12-month survival rate of only 35%, highlighting the need for ongoing research into better treatment options for this group.
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Maternal viral infection and immune response are known to increase the risk of altered development of the foetal brain. Given the ongoing global pandemic of coronavirus disease 2019 (COVID-19), investigating the impact of SARS-CoV-2 on foetal brain health is of critical importance. Here, we report the presence of SARS-CoV-2 in first and second trimester foetal brain tissue in association with cortical haemorrhages.

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