Protective activity of silipide on liver damage in rodents.

The activity of silipide, a silybin-phosphatidylcholine complex (IdB 1016), was tested in different models of liver damage in rodents. After oral administration, silipide exhibited a significant and dose-related protective effect against the hepatotoxicity induced by CCl4, praseodymium, ethanol and galactosamine. The ED50 values for inhibition of the rise in ASAT and ALAT levels caused by CCl4 and praseodymium and for antagonism of the increase in liver triglycerides caused by ethanol ranged from 93 to 156 mg/kg (as silybin).

Comparative bioavailability of Silipide, a new flavanolignan complex, in rats.

The comparative pharmacokinetics of Silipide (IdB 1016, a silybin-phosphatidylcholine complex) and silybin were investigated by measuring unconjugated and total plasma silybin levels as well as total biliary and urinary silybin excretion in rats following administration of a single oral dose (200 mg/kg as silybin). Mean peak levels of unconjugated and total silybin after IdB 1016 were 8.17 and 74.

Effects of Vaccinium Myrtillus anthocyanosides on arterial vasomotion.

The effects of Vaccinium Myrtillus anthocyanosides (Myrtocyan, VMA; CAS 84082-34-8) on arteriolar vasomotion were assessed in cheek pouch microcirculation of anesthetized hamsters and in skeletal muscle microvasculature of unanesthetized hamster skin fold window preparation. Intravenously injected VMA induced vasomotion in cheek pouch arterioles and terminal arterioles with higher frequency in smaller vessels. In the skeletal muscle arteriolar networks VMA increased vasomotion frequency and amplitude in all vessel orders.

Studies on the antioxidant and free radical scavenging properties of IdB 1016 a new flavanolignan complex.

Silybin has been complexed in 1:1 ratio with phosphatidyl choline to give IdB 1016 in order to increase its bioavailability. The antioxidant and free radical scavenger action of this new form of silybin has been evaluated. One hour after the intragastric administration to rats of IdB 1016 (1.

Experimental study on the action of diltiazem on detrusor muscle and clinical evaluation in patients with detrusor hyperactivity.

Diltiazem added to the medium before administration of the agonist, caused a concentration-dependent antagonism of potassium chloride-induced contractions in strips of rat detrusor and human detrusor. When added at the time of peak potassium chloride-induced increase in muscle tone, the drug lowered the tone gradually and concentration-dependently. Diltiazem also depressed carbachol-induced contractions.