The impact of chromatin on double-strand break repair: Imaging tools and discoveries.

Eukaryotic nuclei are constantly being exposed to factors that break or chemically modify the DNA. Accurate repair of this DNA damage is crucial to prevent DNA mutations and maintain optimal cell function. To overcome the detrimental effects of DNA damage, a multitude of repair pathways has evolved.

[Shared decision-making using outcome information: qualitative research among patients].

Background: In the period 2019-2022, eight mental health care organizations have been working on the development and implementation of shared decision-making (SDM) using routine outcome monitoring (ROM) as a source of information.

Aim: To obtain insight in needs and experiences of patients among SDM using ROM, and to investigate which implementation approach this requires.

Method: Explorative, qualitative research consisting of semi-structured interviews and focusgroups with patients (n = 101) treated by mental health care organizations across the Netherlands.

[Consultation from centers of excellence in Dutch mental healthcare; the value for patient and specialist].

The consultation function of centers of excellence is still used to a limited extent. In this article we explain possibilities and contributions of highly specialized consultation to support standard mental healthcare by means of vignettes. Case descriptions from the consultation practice of four centers of excellence are presented.

Making waves: Creating water sensitive cities in Australia.

Creating water sensitive cities is a stated goal of Australia's National Water Initiative; however, most Australian cities have made only limited progress toward this goal. This paper summarises an in-depth collaborative research project that sought to understand what is holding back investment in water sensitive cities and identify a road map to address the constraints. The project involved research academics, industry participants, and economic regulation agencies from all major Australian jurisdictions.

The RECQL helicase prevents replication fork collapse during replication stress.

Most tumors lack the G1/S phase checkpoint and are insensitive to antigrowth signals. Loss of G1/S control can severely perturb DNA replication as revealed by slow replication fork progression and frequent replication fork stalling. Cancer cells may thus rely on specific pathways that mitigate the deleterious consequences of replication stress.