Publications by authors named "M M das Chagas Medeiros"
Background: R-Glabridin is a major flavonoid of licorice (Glycyrrhiza glabra) root and known to modulate GABAA receptors, which are targets of many clinical hypnotics. However, R-glabridin hypnotic activity has not been reported in animals.
Methods: Inverted photomotor responses (IPMRs) were used to assess the hypnotic effects of natural R-glabridin and synthetic R/S-glabridin in wild-type zebrafish larvae and transgenic larvae lacking functional GABAA receptor β3 subunits (β30/0).
Leishmaniases affect millions of people around the world, caused by Leishmania parasites. Leishmania are transmitted by female sandflies from Phlebotominae subfamily during their blood meals. In mammals, promastigotes are phagocytosed mainly by macrophages, differentiate into amastigotes and multiply.
View Article and Find Full Text PDFObjective: to verify the effect of educational technologies on the quality of life of people with diabetes.
Method: quasi-experimental study, before-and-after type, developed with a group of 34 people. Six interventions were carried out, in groups or individually, using educational technologies, such as clinical simulators and physical educational games.
Recurrent neurogenic shock as a rare postoperative complication associated with pancreaticoduodenectomy with mesopancreas excision in elderly patient: a case report.
Gland Surg
November 2024
Background: Surgical resection of locally advanced or borderline pancreatic ductal adenocarcinoma is a recognized procedure with curative intent performed in specialized oncology centers. Postoperative dysautonomia such as gastroparesis, mild hypotension, and diarrhea are common in elderly patients undergoing pancreaticoduodenectomy. A distinctive feature of our case, is the severing of an important sympathetic chain by the surgical procedure, leading to recurrent severe neurogenic shock.
View Article and Find Full Text PDFArticle Synopsis
- The microbiome plays a crucial role in host physiology, with well-known effects from bacteria, but less is understood about fungi's contributions.
- In a study on Hawaiian picture-wing flies, antifungal treatments negatively impacted female reproduction, while antibacterial treatments affected male fecundity differently.
- Combining both treatments led to significant reductions in reproduction and altered lipid metabolism, indicating the importance of microbial interactions for maintaining gut health and reproductive success.