Publications by authors named "M M Zhuhua Cai"
Background: The mechanisms underlying esketamine's therapeutic effects remain elusive. The study aimed to explore the impact of single esketamine treatment on LPS-induced adolescent depressive-like behaviors and the role of Nrf2 regulated neuroinflammatory response in esketamine-produced rapid antidepressant efficacy.
Methods: Adolescent male C57BL/6J mice were randomly assigned to three groups: control, LPS, and LPS + esketamine (15 mg/kg, i.
The coherent spin waves, magnons, can propagate without accompanying charge transports and Joule heat dissipation. Room-temperature and long-distance spin waves propagating within nanoscale spin channels are considered promising for integrated magnonic applications, but experimentally challenging. Here we report that long-distance propagation of chiral magnonic edge states can be achieved at room temperature in manganite thin films with long, antiferromagnetically coupled spin spirals (millimetre length) and low magnetic Gilbert damping (~3.
View Article and Find Full Text PDFSkillful seasonal climate prediction is critical for food and water security over the world's heavily populated regions, such as in continental East Asia. Current models, however, face significant difficulties in predicting the summer mean rainfall anomaly over continental East Asia, and forecasting rainfall spatiotemporal evolution presents an even greater challenge. Here, we benefit from integrating the spatiotemporal evolution of rainfall to identify the most crucial patterns intrinsic to continental East-Asian rainfall anomalies.
View Article and Find Full Text PDFBackground: The peripheral nervous system (PNS) exhibits remarkable regenerative capability after injury. PNS regeneration relies on neurons themselves as well as a variety of other cell types, including Schwann cells, immune cells, and non-neuronal cells.
Objectives: This paper focuses on summarizing the critical roles of immune cells (SCs) in the injury and repair processes of the PNS.
Article Synopsis
- Postinterventional restenosis poses challenges in treating peripheral vascular disease, as current drugs hinder endothelial repair while preventing neointima hyperplasia.
- Stem cell-derived exosomes offer therapeutic benefits by delivering functional microRNAs but face limitations in targeting and tissue uptake in injured vessels.
- To improve efficacy, researchers created platelet-mimetic exosomes (PM-EXOs) that enhance targeting to vascular injuries and promote endothelial repair with minimal side effects, demonstrating significant potential in reducing neointima formation.